Pub. Date : 2005 Dec 15
PMID : 16357153
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have shown that COX-2 inhibition sensitizes human colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inducing clustering of the TRAIL receptor DR5 at the cell surface and the redistribution of the death-inducing signaling complex components (DR5, FADD, and procaspase-8) into cholesterol-rich and ceramide-rich domains known as caveolae. | Cholesterol | TNF receptor superfamily member 10b | Homo sapiens |