Title : The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema.

Pub. Date : 2006 Feb 28

PMID : 16356516






2 Functional Relationships(s)
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1 In the middle of the light phase, ghrelin significantly increased feeding up to 2 h after injection in ad libitum fed rats (BW 130 g; food intake 1 h after injection: NaCl 0.4 +/- 0.2 g versus ghrelin 1.2 +/- 0.3 g [p < 0.05]). Sodium Chloride ghrelin and obestatin prepropeptide Rattus norvegicus
2 However repeated ghrelin injection (15 microg/kg/day once daily at light onset) over 10 days significantly increased food intake in rats (BW 400-460 g) starting from day 4 of the experiment (24 h food intake: NaCl approx. Sodium Chloride ghrelin and obestatin prepropeptide Rattus norvegicus