Title : Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.

Pub. Date : 2006 Feb 14

PMID : 16337154






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism. Phosphocreatine poly(ADP-ribose) polymerase 1 Homo sapiens