Title : 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

Pub. Date : 2006 Apr

PMID : 16332727






1 Functional Relationships(s)
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1 The subsequent downstream effects of DIM/DIM-C-pPhtBu- and Tg-induced ER stress included CHOP-dependent induction of death receptor DR5 and subsequent cleavage of caspase 8, caspase 3, Bid and PARP. Thapsigargin DNA damage inducible transcript 3 Homo sapiens