Title : Angiotensin II receptor subtypes play opposite roles in regulating phosphatidylinositol hydrolysis in rat skin slices.

Pub. Date : 1992 Jul 15

PMID : 1632771






1 Functional Relationships(s)
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1 Losartan, the Ang II AT1 antagonist, at a dose of 10(-4) M blocked the effect of Ang II, while PD123319, the Ang II AT2 antagonist, had no antagonistic action; PD123319 at the higher dose of 10(-3) M, however, potentiated the effect of Ang II on PI hydrolysis. PD 123319 angiotensin II receptor, type 1a Rattus norvegicus