Title : Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer.

Pub. Date : 2005 Nov

PMID : 16317086






6 Functional Relationships(s)
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1 Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
3 Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
4 Nicotine (200 microg/mL) stimulated gastric cancer cell proliferation, which was blocked by SC-236 (a highly selective COX-2 inhibitor) and CBO-P11 (a VEGFR inhibitor). Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
5 The activity of matrix metalloproteinases 2 and 9 and protein expressions of plasminogen activators (urokinase-type plasminogen activator and its receptor), which are the indicators of invasion and migration processes, were increased by nicotine but blocked by COX-2 and VEGFR inhibitors. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
6 Taken together, our results reveal that the promoting action of nicotine on angiogenesis, tumor invasion, and metastasis is COX-2/VEGF/VEGFR dependent. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens