Pub. Date : 2005 Nov
PMID : 16317086
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
2 | Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
3 | Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
4 | Nicotine (200 microg/mL) stimulated gastric cancer cell proliferation, which was blocked by SC-236 (a highly selective COX-2 inhibitor) and CBO-P11 (a VEGFR inhibitor). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
5 | The activity of matrix metalloproteinases 2 and 9 and protein expressions of plasminogen activators (urokinase-type plasminogen activator and its receptor), which are the indicators of invasion and migration processes, were increased by nicotine but blocked by COX-2 and VEGFR inhibitors. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
6 | Taken together, our results reveal that the promoting action of nicotine on angiogenesis, tumor invasion, and metastasis is COX-2/VEGF/VEGFR dependent. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |