Pub. Date : 2006 Apr 6
PMID : 16301993
18 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 2 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 3 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 4 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 5 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 6 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 7 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 8 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 9 | We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 10 | These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 11 | These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 12 | These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 13 | However, Gi inhibitor pertussis toxin or dominant-negative H-Ras still significantly inhibited LPA-stimulated cell migration in cells expressing the membrane anchored FAK containing a mutation in the autophosphorylation site [CD2-FAK(Y397A)]. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 14 | However, Gi inhibitor pertussis toxin or dominant-negative H-Ras still significantly inhibited LPA-stimulated cell migration in cells expressing the membrane anchored FAK containing a mutation in the autophosphorylation site [CD2-FAK(Y397A)]. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 15 | These results suggest that FAK autophosphorylation plays a role in LPA-stimulated cell migration. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 16 | With the aid of p115RhoGEF-RGS, G12 and G13 minigenes to inhibit G12/13, we found that the G12/13 pathway was required for LPA-induced FAK autophosphorylation and efficient cell migration. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 17 | Moreover, LPA activated RhoA and Rho kinase (ROCK) in a G12/13-dependent manner and their activities were required for LPA-induced FAK autophosphorylation. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |
| 18 | Our studies show that the G12/13-RhoA-ROCK signaling pathway mediates LPA-induced FAK autophosphorylation and contributes to LPA-stimulated cell migration. | lysophosphatidic acid | protein tyrosine kinase 2 | Homo sapiens |