Title : Streptozotocin (STZ) mediates acute upregulation of serum and pancreatic osteopontin (OPN): a novel islet-protective effect of OPN through inhibition of STZ-induced nitric oxide production.

Pub. Date : 2005 Nov

PMID : 16293771






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels. Aspartic Acid nitric oxide synthase 2 Rattus norvegicus
2 OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels. Aspartic Acid nitric oxide synthase 2 Rattus norvegicus