Title : IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

Pub. Date : 2005 Dec 14

PMID : 16290312






2 Functional Relationships(s)
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1 IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2? Ceramides AKT serine/threonine kinase 1 Homo sapiens
2 Ceramide decreases Akt phosphorylation during apoptotic process whereas a simultaneous treatment with IGF-I increases Akt phosphorylation. Ceramides AKT serine/threonine kinase 1 Homo sapiens