Title : STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

Pub. Date : 2005 Nov

PMID : 16285960






2 Functional Relationships(s)
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1 RESULTS: Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 terminus are acetylated by p300. Lysine E1A binding protein p300 Mus musculus
2 Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation. Lysine E1A binding protein p300 Mus musculus