Pub. Date : 2006 Apr
PMID : 16282361
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 2 | Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 3 | Previous studies showed that human ABCC4 is localized to the sinusoidal membrane of hepatocytes and mediates, among other substrates, the cotransport of reduced glutathione (GSH) with bile acids. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 4 | Previous studies showed that human ABCC4 is localized to the sinusoidal membrane of hepatocytes and mediates, among other substrates, the cotransport of reduced glutathione (GSH) with bile acids. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 5 | In the present study, using inside-out membrane vesicles, we demonstrated that human ABCC4 in the presence of physiological concentrations of GSH has a high affinity for the taurine and glycine conjugates of the common natural bile acids as well as the unconjugated bile acid cholate. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 6 | Chenodeoxycholyltaurine and chenodeoxycholylglycine were the GSH cosubstrates with the highest affinities for ABCC4, with K(m) values of 3.6 and 5.9 microM, respectively. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 7 | Ursodeoxycholyltaurine and ursodeoxycholylglycine were cotransported together with GSH by ABCC4 with K(m) values of 7.8 and 12.5 microM, respectively, but no transport of ursodeoxycholate and deoxycholate was observed. | Glutathione | ATP binding cassette subfamily C member 4 | Homo sapiens |