Title : Tyrosine-612 in PDE5 contributes to higher affinity for vardenafil over sildenafil.

Pub. Date : 2006 May-Jun

PMID : 16281046






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In co-crystals with PDE5, one of the rings of vardenafil or sildenafil interacts with Tyr(612), a catalytic site AA, via (1) a hydrogen bond with a water molecule and (2) hydrophobic bonds. Water phosphodiesterase 5A Homo sapiens