Title : Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase.

Pub. Date : 2006 Jan 13

PMID : 16278211






2 Functional Relationships(s)
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1 Mammalian cells contain mono-ADP-ribosyltransferases that catalyze the formation of ADP-ribose-(arginine) protein, which can be cleaved by a 39-kDa ADP-ribose-(arginine) protein hydrolase (ARH1), resulting in release of free ADP-ribose and regeneration of unmodified protein. Ribose ADP-ribosylarginine hydrolase Homo sapiens
2 We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Ribose ADP-ribosylarginine hydrolase Homo sapiens