Title : Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts.

Pub. Date : 2006 Mar 6

PMID : 16266722






3 Functional Relationships(s)
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1 The present study was undertaken to determine the effect of nicotine and LPS on the expression of macrophage colony-stimulating factor (M-CSF), osteoprotegerin (OPG), and prostaglandin E2 (PGE2) in osteoblasts, and the indirect effect of nicotine and LPS on the formation of osteoclast-like cells. Nicotine TNF receptor superfamily member 11b Homo sapiens
2 The present study was undertaken to determine the effect of nicotine and LPS on the expression of macrophage colony-stimulating factor (M-CSF), osteoprotegerin (OPG), and prostaglandin E2 (PGE2) in osteoblasts, and the indirect effect of nicotine and LPS on the formation of osteoclast-like cells. Nicotine TNF receptor superfamily member 11b Homo sapiens
3 OPG expression increased in the initial stages of culture with nicotine and LPS but decreased in the later stages of culture. Nicotine TNF receptor superfamily member 11b Homo sapiens