Title : Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth.

Pub. Date : 2006 Mar

PMID : 16261397






1 Functional Relationships(s)
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1 These findings suggest that ERalpha function in Tam-R cells is maintained as a consequence of EGFR/MAPK-mediated phosphorylation at serine residue 118 resulting in the generation of a self-propogating autocrine growth-regulatory loop through the ERalpha-mediated production of AR. Serine epidermal growth factor receptor Homo sapiens