Pub. Date : 2005 Nov
PMID : 16261361
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the likelihood of artemisinin and thiabendazole causing pharmacokinetic interactions involving cytochrome P450 (CYP1A2) in humans given their potent inhibitory effects on the isoform in vitro. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 4 | RESULTS: Using the ratio of paraxanthine to caffeine after 4 h as an indicator of CYP1A2 activity, thiabendazole and artemisinin inhibited 92 and 66%, respectively, of the enzyme activity in vivo. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 5 | CONCLUSIONS: Co-administration of thiabendazole or artemisinin with CYP1A2 substrates could result in clinically significant effects. | Thiabendazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |