Pub. Date : 2006 Mar
PMID : 16257278
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 2 | A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 3 | As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 4 | Both subgroups increased their IGF-1 production similarly in response to PGE2, while the high OA subgroup showed a blunted response to PTH compared to the low OA group. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 5 | Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX). | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 6 | The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 7 | The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 8 | Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |
| 9 | These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA. | Dinoprostone | insulin like growth factor 1 | Homo sapiens |