PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16257278-4	2006	A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob.	Dinoprostone	54-58	insulin like growth factor 1	Homo sapiens	70-98	
16257278-4	2006	A linear relationship was observed between endogenous PGE2 levels and insulin-like growth factor 1 (IGF-1) levels in OA Ob.	Dinoprostone	54-58	insulin like growth factor 1	Homo sapiens	100-105	
16257278-5	2006	As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob.	Dinoprostone	33-37	insulin like growth factor 1	Homo sapiens	63-68	
16257278-6	2006	Both subgroups increased their IGF-1 production similarly in response to PGE2, while the high OA subgroup showed a blunted response to PTH compared to the low OA group.	Dinoprostone	73-77	insulin like growth factor 1	Homo sapiens	31-36	
16257278-7	2006	Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX).	Dinoprostone	92-96	insulin like growth factor 1	Homo sapiens	70-75	
16257278-8	2006	The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.	Dinoprostone	4-8	insulin like growth factor 1	Homo sapiens	34-39	
16257278-8	2006	The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.	Dinoprostone	4-8	insulin like growth factor 1	Homo sapiens	241-246	
16257278-10	2006	Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob.	Dinoprostone	81-85	insulin like growth factor 1	Homo sapiens	97-102	
16257278-11	2006	These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA.	Dinoprostone	82-86	insulin like growth factor 1	Homo sapiens	34-39