Title : Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV.

Pub. Date : 2005 Nov

PMID : 16253890






3 Functional Relationships(s)
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1 I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120. Carbohydrates inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
2 I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120. Carbohydrates inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
3 I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120. Carbohydrates inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens