Title : Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.

Pub. Date : 2006 Feb

PMID : 16251482






1 Functional Relationships(s)
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1 After being injected with cisplatin (ip, 45 mg/kg), mice drinking 2% acetone with increased CYP2E1 levels exhibited elevated levels of serum ALT and AST, liver caspase-3 activity and positive staining of TUNEL increased, and histopathology indicated the presence of necrotic foci in livers of acetone plus cisplatin-treated mice. ip caspase 3 Mus musculus