Title : Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.

Pub. Date : 2005 Nov 7

PMID : 16242127






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 NO donors such as S-nitrosoglutathione (GSNO), S-nitroso-N-acetylpenicillamine, and 3-morpholinosydnonimine significantly increased the nitrite concentration while they inhibited the ALDH2 activity. S-Nitrosoglutathione aldehyde dehydrogenase 2 family member Rattus norvegicus
2 NO donors such as S-nitrosoglutathione (GSNO), S-nitroso-N-acetylpenicillamine, and 3-morpholinosydnonimine significantly increased the nitrite concentration while they inhibited the ALDH2 activity. S-Nitrosoglutathione aldehyde dehydrogenase 2 family member Rattus norvegicus
3 Addition of GSH-ethylester (GSH-EE) completely blocked the GSNO-mediated ALDH2 inhibition and increased nitrite concentration. S-Nitrosoglutathione aldehyde dehydrogenase 2 family member Rattus norvegicus
4 The anti-nitrosocysteine antibody recognized the immunopurified ALDH2 only from the GSNO-treated samples. S-Nitrosoglutathione aldehyde dehydrogenase 2 family member Rattus norvegicus