Title : Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice.

Pub. Date : 2005 Dec

PMID : 16219031






1 Functional Relationships(s)
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1 In parallel, the 5-HT 1A autoreceptor-mediated [35S]GTP-gamma-S binding induced by 5-carboxamidotryptamine onto the DRN in brainstem sections was significantly decreased in GR 205171-treated mice. Guanosine 5'-O-(3-Thiotriphosphate) 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus