Title : Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II.

Pub. Date : 2005 Nov

PMID : 16203876






3 Functional Relationships(s)
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1 Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues. Iron angiotensinogen Rattus norvegicus
2 Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues. Iron angiotensinogen Rattus norvegicus
3 Abnormal lipid metabolism may be associated with upregulation of TGF-beta1 expression and aberrant iron homeostasis in the kidneys of angiotensin II-infused animals. Iron angiotensinogen Rattus norvegicus