Title : Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects.

Pub. Date : 2005 Jun

PMID : 16199376






1 Functional Relationships(s)
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1 In vitro, these biotinylated immunoliposomes were used to by-pass P-glycoprotein in multidrug-resistant RBE4 brain capillary endothelial cells and thereby to achieve 2- to 3-fold higher intracellular accumulation of liposomal daunomycin as compared to free drug. Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus