Title : AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.

Pub. Date : 2005 Aug

PMID : 16193242






2 Functional Relationships(s)
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1 Since Angiotensin II type 1 (AT1) receptor can be involved in TNF-alpha production, we have investigated whether early short-term treatment with irbesartan, an AT1 receptor blocker, is able to limit TNF-alpha production within the heart and to improve cardiac function and geometry following MI in rats. Irbesartan tumor necrosis factor Rattus norvegicus
2 On day 7, cardiac TNF-alpha was significantly reduced in MI rats receiving irbesartan (p < 0.05). Irbesartan tumor necrosis factor Rattus norvegicus