Pub. Date : 2005 Oct 28
PMID : 16185715
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Mass spectrometry was used to probe changes in hydrogen/deuterium exchange in the MAP kinase, ERK2, in the presence and absence of the ATP analogue, AMP-PNP. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In both active and inactive forms of ERK2, protection from hydrogen exchange by AMP-PNP binding was observed within conserved ATP binding motifs in the N-terminal lobe, which are known to directly interact with nucleotide in various protein kinases. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |