Title : Asp746 to glycine change may have a greater influence than Cys751 to serine change in accounting for ligand selectivity between EGFR and HER-2 at the ATP site.

Pub. Date : 2005 May

PMID : 16184431






1 Functional Relationships(s)
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1 This might be an important contributory factor to differences in selectivity of the ligands between the two kinases, probably more so than the conservative change of Cys751 of EGFR to serine in HER-2 at the ATP site. Serine epidermal growth factor receptor Homo sapiens