Title : Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair.

Pub. Date : 2005 Sep 28

PMID : 16173754






1 Functional Relationships(s)
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1 We report, using path sampling simulations and a reaction network model, strikingly different transition states in DNA polymerase beta"s conformational closing for correct dCTP versus incorrect dATP incoming nucleotide opposite a template G. The cascade of transition states leads to differing active-site assembly processes toward the "two-metal-ion catalysis" geometry. 2'-deoxycytidine 5'-triphosphate DNA polymerase beta Homo sapiens