Pub. Date : 2006 Jan 12
PMID : 16170359
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 2 | We recently reported that curcumin inhibited the growth of human colon cancer-derived Moser cells by suppressing gene expression of cyclinD1 and EGFR. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 3 | The aim of the present study was to explore the molecular mechanisms underlying curcumin inhibition of gene expression of EGFR in colon cancer cells. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 4 | The generality of the inhibitory effect of curcumin on gene expression of EGFR was verified in other human colon cancer-derived cell lines, including Caco-2 and HT-29 cells. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 5 | Promoter deletion assays and site-directed mutageneses identified a binding site for the transcription factor early growth response-1 (Egr-1) in egfr promoter as a putative curcumin response element in regulating the promoter activity of the gene in Moser cells. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 6 | Taken together, our results demonstrated that curcumin inhibited human colon cancer cell growth by suppressing gene expression of EGFR through reducing the trans-activation activity of Egr-1. | Curcumin | epidermal growth factor receptor | Homo sapiens |