Title : Quantitative structure-activity relationship and quantitative structure-pharmacokinetics relationship of 1,4-dihydropyridines and pyridines as multidrug resistance modulators.

Pub. Date : 2005 Dec

PMID : 16158213






3 Functional Relationships(s)
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1 PURPOSE: The aim of this study was to develop quantitative structure-activity/pharmacokinetic relationships (QSAR/QSPKR) for a series of synthesized 1,4-dihydropyridines (DHPs) and pyridines as P-glycoprotein (P-gp) inhibitors. Pyridines ATP binding cassette subfamily B member 1 Homo sapiens
2 PURPOSE: The aim of this study was to develop quantitative structure-activity/pharmacokinetic relationships (QSAR/QSPKR) for a series of synthesized 1,4-dihydropyridines (DHPs) and pyridines as P-glycoprotein (P-gp) inhibitors. Pyridines ATP binding cassette subfamily B member 1 Homo sapiens
3 CONCLUSION: QSAR/QSPKR models were developed, and the QSAR models were capable of identifying synthesized 1,4-DHPs and pyridines with potent P-gp inhibition and reduced Ca2+ channel binding. Pyridines ATP binding cassette subfamily B member 1 Homo sapiens