Pub. Date : 2005 Oct
PMID : 16151644
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Etoposide activated p38, inhibited the G2/M transition with the persistent inhibitory phosphorylation of Cdc2 on Tyr15, and caused apoptosis of Daudi cells. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 2 | SB203580, a specific inhibitor of p38alpha and p38beta, similarly reduced the inhibitory phosphorylation of Cdc2 as well as G2/M arrest and augmented apoptosis of Daudi cells treated with etoposide. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |
| 3 | These results suggest that p38 plays a role in G2/M checkpoint activation through induction of the persistent inhibitory phosphorylation of Cdc2 and, thereby, inhibits apoptosis of Daudi cells treated with etoposide. | Etoposide | cyclin dependent kinase 1 | Homo sapiens |