Title : DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy.

Pub. Date : 2006 Jul 28

PMID : 16143448






2 Functional Relationships(s)
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1 This study was designed to determine the individual influences of doxorubicin and cisplatin on the degree of DNA damage, DNA repair and hMSH2 and the hMLH1 protein expression in peripheral blood lymphocytes (PBL) and their correlations with the clinical response. Cisplatin mutS homolog 2 Homo sapiens
2 In 83% of cisplatin-treated patients with CR the hMLH1 and hMSH2 expression at T24 was higher than the mean. Cisplatin mutS homolog 2 Homo sapiens