Title : Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes.

Pub. Date : 2005 Sep

PMID : 16141567






1 Functional Relationships(s)
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1 The effects of five antifungal drugs, fluconazole, itraconazole, micafungin, miconazole, and voriconazole, on cytochrome P450 (CYP) 2C9-mediated tolbutamide hydroxylation, CYP2C19-mediated S-mephenytoin 4"-hydroxylation, and CYP3A4-mediated nifedipine oxidation activities in human liver microsomes were compared. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens