Title : Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors.

Pub. Date : 2005 Oct 15

PMID : 16140252






1 Functional Relationships(s)
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1 Using the kinase inhibitors BMS-250595, purvalanol B, AG-12275, flavopiridol, and several other compounds, it is demonstrated that one can obtain excellent comparisons between the Kd values of binding to CDK2 obtained by TdCD and ITC. alvocidib cyclin dependent kinase 2 Homo sapiens