Title : Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.

Pub. Date : 1992 Jun 12

PMID : 1613744






2 Functional Relationships(s)
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1 The hypothesis that clinical side effects of the aldose reductase inhibitor (ARI) sorbinil were related to its hydantoin ring led to a bioisosteric analysis and replacement of the hydantoin by a spiro hydroxy acetic acid moiety as in 40. Hydantoins aldo-keto reductase family 1 member B1 Rattus norvegicus
2 The hypothesis that clinical side effects of the aldose reductase inhibitor (ARI) sorbinil were related to its hydantoin ring led to a bioisosteric analysis and replacement of the hydantoin by a spiro hydroxy acetic acid moiety as in 40. Hydantoins aldo-keto reductase family 1 member B1 Rattus norvegicus