Title : Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene.

Pub. Date : 2005 Dec 30

PMID : 16125881






2 Functional Relationships(s)
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1 The subjects" genetic polymorphisms in the genes that encode the styrene-metabolizing enzymes CYP2E1, CYP2B6, EPHX1, GSTM1, GSTT1 and GSTP1 were determined. Styrene epoxide hydrolase 1 Homo sapiens
2 When the combined influence of the CYP2B6 genotype and the predicted activity of EPHX1 were examined, urinary metabolites in subjects with low enzyme activity were lower than in those with medium or high activity after high styrene exposure (>or=50 ppm). Styrene epoxide hydrolase 1 Homo sapiens