Pub. Date : 2006 Mar
PMID : 16123776
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. | Cocaine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 2 | Mice lacking DARPP-32, a striatal-enriched phosphoprotein, show abnormal behavioral and biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP-32 in these responses is unknown. | Cocaine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 3 | We show here that mutation of Thr-34 in DARPP-32 mimicked the behavioral phenotype of the constitutive DARPP-32 knockout in cocaine-induced place conditioning, locomotor activity, and sensitization paradigms. | Cocaine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 4 | We show here that mutation of Thr-34 in DARPP-32 mimicked the behavioral phenotype of the constitutive DARPP-32 knockout in cocaine-induced place conditioning, locomotor activity, and sensitization paradigms. | Cocaine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 5 | Consistent with these behavioral findings, we found that cocaine regulation of gene expression in striatum, including the acute induction of the immediate early genes c-fos and arc (activity-regulated cytoskeletal-associated gene), was abolished in DARPP-32 Thr-34 mutants, but not in Thr-75 mutants. | Cocaine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |