Title : Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension.

Pub. Date : 2005 Sep

PMID : 16116048






3 Functional Relationships(s)
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1 Six or 13 days of Ang II infusion significantly attenuated the vasoconstrictor responses to ATP and beta,gamma-methylene ATP (P<0.05). 5'-adenylyl (beta,gamma-methylene)diphosphonate angiotensinogen Rattus norvegicus
2 Renal myocyte intracellular calcium responses to ATP or beta,gamma-methylene ATP were also decreased in Ang II hypertensive rats. 5'-adenylyl (beta,gamma-methylene)diphosphonate angiotensinogen Rattus norvegicus
3 The peak increases in [Ca2+]i in response to beta,gamma-methylene ATP were also reduced in Ang II hypertensive rats. 5'-adenylyl (beta,gamma-methylene)diphosphonate angiotensinogen Rattus norvegicus