Pub. Date : 2006 May
PMID : 16109481
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | According to the molecular switch hypothesis of GTPase function GTP-loading of RhoA should be sufficient to activate its effectors uniformly. | Guanosine Triphosphate | ras homolog family member A | Rattus norvegicus |
| 2 | However, when monitoring NGF-induced binding of GTP-RhoA to multiple targets, we noted differential interactions with its effectors. | Guanosine Triphosphate | ras homolog family member A | Rattus norvegicus |
| 3 | Therefore, phosphorylation of serine(188) may serve as a novel secondary switch of RhoA capable of overriding GTP-binding-elicited effector activation to a subset of targets such as ROK, which interact with the C-terminus of RhoA. | Guanosine Triphosphate | ras homolog family member A | Rattus norvegicus |
| 4 | Therefore, phosphorylation of serine(188) may serve as a novel secondary switch of RhoA capable of overriding GTP-binding-elicited effector activation to a subset of targets such as ROK, which interact with the C-terminus of RhoA. | Guanosine Triphosphate | ras homolog family member A | Rattus norvegicus |