Protein Name ras homolog family member A
Organism Rattus norvegicus
Gene ID 117273
Gene Symbol

Rhoa

UniProt P61589 (RHOA_RAT)
Relationships Total Number of functionally related compound(s) : 411
Total Number of Articles : 594
Description

ras homolog family member A

Gene Summary

Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of cellular protein metabolic process; and regulation of neuron projection development. Acts upstream of or within negative regulation of vascular associated smooth muscle cell migration and negative regulation of vascular associated smooth muscle cell proliferation. Located in axon; cytosol; and membrane. Used to study membranous glomerulonephritis. Biomarker of asthma; fetal alcohol syndrome; hypertension; obesity; and pulmonary hypertension. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • transforming protein RhoA
  • plysia ras-related homolog A2
  • ras homolog gene family, member A
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Properties