Pub. Date : 2005 Aug
PMID : 16103452
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thus, deficient folate status has been hypothesized to be associated primarily with ER gene-negative breast tumors, but data relating folate intake to breast cancer risk according to ER status are sparse. | Folic Acid | estrogen receptor 1 | Homo sapiens |
| 2 | Higher total folate intake was significantly associated with lower risk of developing ER- but not ER+ breast cancer; the multivariable relative risks (RR) and 95% confidence intervals (95% CI) comparing the highest to the lowest quintile were 0.81 (0.66-0.99) for ER- tumors and 1.00 (0.89-1.14) for ER+ tumors. | Folic Acid | estrogen receptor 1 | Homo sapiens |
| 3 | The inverse association between total folate intake and ER- breast cancer was mainly present among women consuming at least 15 g/d of alcohol (multivariable RR, 0.46; 95% CI,=0.25-0.86; top versus bottom quintile). | Folic Acid | estrogen receptor 1 | Homo sapiens |
| 4 | These findings support the hypothesis that higher folate intake reduces the risk of developing ER- breast cancer. | Folic Acid | estrogen receptor 1 | Homo sapiens |