Title : Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.

Pub. Date : 2005 Aug 15

PMID : 16103098






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine-glutamate exchange and thereby regulates intracellular glutathione levels. Glutathione solute carrier family 7 member 11 Homo sapiens
2 SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine-glutamate exchange and thereby regulates intracellular glutathione levels. Glutathione solute carrier family 7 member 11 Homo sapiens
3 These results indicate that SLC7A11 mediates cellular uptake of L-alanosine but confers resistance to geldanamycin by supplying cystine for glutathione maintenance. Glutathione solute carrier family 7 member 11 Homo sapiens
4 SLC7A11 expression could serve as a predictor of cellular response to L-alanosine and glutathione-mediated resistance to geldanamycin, yielding a potential target for increasing chemosensitivity to multiple drugs. Glutathione solute carrier family 7 member 11 Homo sapiens