Pub. Date : 2005 Aug 15
PMID : 16103098
4 Functional Relationships(s)Download |
||||||
Sentence | Compound Name | Protein Name | Organism |
|||
1 | SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine-glutamate exchange and thereby regulates intracellular glutathione levels. | Glutathione | solute carrier family 7 member 11 | Homo sapiens | ||
2 | SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine-glutamate exchange and thereby regulates intracellular glutathione levels. | Glutathione | solute carrier family 7 member 11 | Homo sapiens | ||
3 | These results indicate that SLC7A11 mediates cellular uptake of L-alanosine but confers resistance to geldanamycin by supplying cystine for glutathione maintenance. | Glutathione | solute carrier family 7 member 11 | Homo sapiens | ||
4 | SLC7A11 expression could serve as a predictor of cellular response to L-alanosine and glutathione-mediated resistance to geldanamycin, yielding a potential target for increasing chemosensitivity to multiple drugs. | Glutathione | solute carrier family 7 member 11 | Homo sapiens |