Title : Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor.

Pub. Date : 2005 Sep 16

PMID : 16100051






2 Functional Relationships(s)
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1 This interpretation is supported by the finding that adenosine- and CCPA-induced phosphorylation of ERK, JNK, and AKT are inhibited by pertussis toxin (inactivator of Gi proteins) and by DPCPX (A1-selective antagonist), but not by SCH58261, MRS1706, and VUF5574 (A2A-, A2B-, and A3-selective antagonists, respectively). 2-chloro-N(6)cyclopentyladenosine mitogen-activated protein kinase 1 Homo sapiens
2 In addition, adenosine- and CCPA-induced phosphorylation of ERK, JNK, and AKT is inhibited, respectively, by U0126, PD98059 (mitogen-activated protein kinase kinase inhibitors), SP600125 (JNK kinase inhibitor), and wortmannin (phosphatidylinositol 3-kinase inhibitor). 2-chloro-N(6)cyclopentyladenosine mitogen-activated protein kinase 1 Homo sapiens