Title : Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.

Pub. Date : 2006 Feb 1

PMID : 16094629






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1 This amazing synergism was accompanied by synergistic modulation of E2F-1 and p27(Kip1), which were reported to mediate the anticancer activities of lovastatin and troglitazone, respectively, and other cell cycle regulating proteins such as CDK2, cyclin A and RB phosphorylation status. Lovastatin cyclin dependent kinase 2 Homo sapiens