Title : Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects.

Pub. Date : 2005 Sep

PMID : 16091841






4 Functional Relationships(s)
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1 Osteocalcin production was evaluated by cultured cells in neridronate 10(-4) M and 10(-6) M, both under basal conditions and after vitamin D3 stimulation. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
2 In the absence of neridronate, vitamin D3 increased osteocalcin production in all cell cultures; under the same conditions, and in the absence of vitamin D3, OA osteoblasts showed a significantly higher osteocalcin production whereas OP osteoblasts showed a significantly lower osteocalcin production compared to the normal osteoblasts, respectively. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
3 In the absence of neridronate, vitamin D3 increased osteocalcin production in all cell cultures; under the same conditions, and in the absence of vitamin D3, OA osteoblasts showed a significantly higher osteocalcin production whereas OP osteoblasts showed a significantly lower osteocalcin production compared to the normal osteoblasts, respectively. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
4 In the absence of neridronate, vitamin D3 increased osteocalcin production in all cell cultures; under the same conditions, and in the absence of vitamin D3, OA osteoblasts showed a significantly higher osteocalcin production whereas OP osteoblasts showed a significantly lower osteocalcin production compared to the normal osteoblasts, respectively. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens