Pub. Date : 2005 Dec 1
PMID : 16091744
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex. | Melphalan | BCL2 like 11 | Homo sapiens |
| 2 | Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex. | Melphalan | BCL2 like 11 | Homo sapiens |
| 3 | In this study, we demonstrate that melphalan disrupts the Mcl-1/Bim complex whereas the Bcl-2/Bim complex is not modified. | Melphalan | BCL2 like 11 | Homo sapiens |
| 4 | Thus, we can hypothesize that the cleaved 26 kDa proapoptotic Mcl-1 and the 19 and 12 kDa of Bim, generated during melphalan treatment could contribute to the amplification loop of apoptosis. | Melphalan | BCL2 like 11 | Homo sapiens |