Title : Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression.

Pub. Date : 2006 Apr 15

PMID : 16084549






3 Functional Relationships(s)
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1 Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Results showed that AMPH treatment decreased food intake, which was correlated with changes of NPY mRNA level, but increased c-fos, c-jun and superoxide dismutase (SOD) mRNA levels in hypothalamus. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 It was suggested that c-fos/c-jun signaling might involve in the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus