Title : Janus kinase 2 enhances the stability of the mature growth hormone receptor.

Pub. Date : 2005 Nov

PMID : 16081639






1 Functional Relationships(s)
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1 Although the absence of JAK2 precluded GH-stimulated signaling, GH-induced GHR disulfide linkage (a proxy for the GH-induced conformational changes in the GHR dimer) proceeded independent of JAK2 expression, indicating that the earliest steps in GH-induced GHR triggering are not prevented by the absence of JAK2. Disulfides growth hormone receptor Homo sapiens