Pub. Date : 2005 Sep
PMID : 16077934
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. | betulinic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Further, BA strongly induced AKT phosphorylation in a similar pattern. | betulinic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | AKT activation started 15 min post-treatment, peaked at approximately 1 h, remained elevated for 4 h and returned to basal level within 8 h. BA also induced ERK activation and, in contrast, weakly induced JNK and p38 activation. | betulinic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. | betulinic acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Collectively, we conclude that betulinic acid transiently activated the EGFR/AKT cell survival pathway and induced survivin expression, contributing to less sensitivity in human melanoma cells. | betulinic acid | AKT serine/threonine kinase 1 | Homo sapiens |