Title : Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells.

Pub. Date : 2005 Aug 1

PMID : 16061644






1 Functional Relationships(s)
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1 Inhibition of BCRP-mediated efflux of dihydrotestosterone by novobiocin or fumitremorgin C in a rat prostate progenitor cell line that expresses BCRP and AR mRNAs, but minimal AR protein, results in stabilization and nuclear translocation of AR protein, providing a mechanism for lack of AR protein in BCRP-expressing stem cells. Novobiocin ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens